Star opener David Warner and spinner Nathan Lyon return to face India on Wednesday in the fourth one-day international with the series already wrapped up.
Cricket Australia announced Monday that batsman Usman Khawaja and debutant bowler Joel Paris would stand aside for the game in Canberra.
World Cup holders Australia have won the three opening ODIs and also have a fifth to play in Sydney on Saturday.
Warner stood aside for matches two and three for the birth of his second child.
“Our choice of Nathan Lyon comes off the back of good form in the KFC BBL (big Bash League) and we decided the time is right to have another look at him in the shorter forms of the game,” said national selector Rod Marsh.
A three-match Twenty20 series starts against India on January 26.